HEALTH● LOWAug 26 · Aug 26, 2026, 4:15 AM
The runner high was attributed to endorphins for decades , but circulating endorphins cannot readily cross the blood – brain barrier and blocking opioid receptors does not prevent runners from feeling euphoric . Evidence now points primarily to endoc...
scienceblog.com · United States
New evidence suggests that the "runner's high" is primarily attributed to endocannabinoids, rather than endorphins, due to their ability to cross the blood-brain barrier. This represents an update in scientific understanding of physiological responses to exercise.
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